10/5/2023 0 Comments Silver sulfadiazine cream expiredIf allergic reactions attributable to treatment with silver sulfadiazine occur, continuation of therapy must be weighed against the potential hazards of the particular allergic reaction.įungal proliferation in and below the eschar may occur. There is a potential cross-sensitivity between silver sulfadiazine and other sulfonamides. Some of the reactions which have been associated with sulfonamides are as follows: blood dyscrasias including agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, and hemolytic anemia dermatologic and allergic reactions, including life-threatening cutaneous reactions gastrointestinal reactions, hepatitis and hepatocellular necrosis CNS reactions and toxic nephrosis. Although few have been reported, it is possible that any adverse reaction associated with sulfonamides may occur. Silver sulfadiazine is not a carbonic anhydrase inhibitor and may be useful in situations where such agents are contraindicated.Ībsorption of silver sulfadiazine varies depending upon the percent of body surface area and the extent of the tissue damage. Silver Sulfadiazine Number of Sensitive Strains / Sulfadiazine Cream, USP 1% Concentration of Silver sulfadiazine acts only on the cell membrane and cell wall to produce its bactericidal effect. Studies utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemical techniques have revealed that the mechanism of action of silver sulfadiazine on bacteria differs from silver nitrate and sodium sulfadiazine. Sufficient data have been obtained to demonstrate that silver sulfadiazine will inhibit bacteria that are resistant to other antimicrobial agents and that the compound is superior to sulfadiazine. ![]() Results from in vitro testing are listed below. It is bactericidal for many gram-negative and gram-positive bacteria as well as being effective against yeast. Any duplication or distribution of the information contained herein is strictly prohibited.Silver sulfadiazine has broad antimicrobial activity. Links to other sites are provided for information only-they do not constitute endorsements of those other sites. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. is also a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. Learn more about A.D.A.M.'s editorial policy, editorial process and privacy policy. is among the first to achieve this important distinction for online health information and services. follows rigorous standards of quality and accountability. is accredited by URAC, also known as the American Accreditation HealthCare Commission (URAC's accreditation program is an independent audit to verify that A.D.A.M. Do not apply extra medicine to make up for a missed dose.Ī.D.A.M., Inc. If it is almost time for your next dose, wait until then and apply a regular dose. ![]() You should keep using this medicine until the burned area has healed or is ready for skin grafting.
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